LP17 (TFA)

• Description :

  LP17 (LQVTDSGLYRCVIYHPP) TFA is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 TFA substantially alleviates ischemia-induced infarction and neuronal injury. LP17 TFA can get access into brain and block TREM-1[1].

• Product Name Alternative :

  LQVTDSGLYRCVIYHPP (TFA)

• UNSPSC :

  12352209

• Target :

  Others

• Type :

  Peptides

• Related Pathways :

  Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/lqvtdsglyrcviyhpp-tfa.html

• Purity :

  99.85

• Solubility :

  H2O : 3.33 mg/mL (ultrasonic)

• Smiles :

  O=C([C@@H](N)CC(C)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N2[C@H](C(O)=O)CCC2)=O)CCC1)=O)CC3=CNC=N3)=O)CC4=CC=C(O)C=C4)=O)[C@H](CC)C)=O)C(C)C)=O)CS)=O)CCCNC(N)=N)=O)CC5=CC=C(O)C=C5)=O)CC(C)C)=O)=O)CO)=O)CC(O)=O)=O)[C@@H](C)O)=O)C(C)C)=O)CCC(N)=O.OC(C(F)(F)F)=O.[x]

• Molecular Formula :

  C89H137N23O25S.xC2HF3O2

• Molecular Weight :

  1961.24 (free base)

• References & Citations :

  [1]Pengfei Xu, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019 Jul 19;10 (8) :555.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported