LP17

• Description :

  LP17 (LQVTDSGLYRCVIYHPP) is a BBB-penetrable triggering receptor expressed on myeloid cells (TREM-1) inhibitory peptide. LP17 substantially alleviates ischemia-induced infarction and neuronal injury. LP17 can get access into brain and block TREM-1[1].

• CAS Number :

  [887255-16-5]

• Product Name Alternative :

  LQVTDSGLYRCVIYHPP

• UNSPSC :

  12352209

• Target :

  Others

• Type :

  Peptides

• Related Pathways :

  Others

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/lqvtdsglyrcviyhpp.html

• Purity :

  99.78

• Solubility :

  DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 7 with CH3COOH; heat to 37°C) |H2O : 35.71 mg/mL (adjust pH to 3 with CH3COOH)

• Smiles :

  O=C(N1[C@@H](CCC1)C(O)=O)[C@H]2N(CCC2)C([C@@H](NC([C@@H](NC([C@H]([C@@H](C)CC)NC([C@H](C(C)C)NC([C@H](CS)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC(CNC([C@H](CO)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](C(C)C)NC([C@H](CCC(N)=O)NC([C@@H](N)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC3=CC=C(C=C3)O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)CC5=CN=CN5)=O

• Molecular Formula :

  C89H137N23O25S

• Molecular Weight :

  1961.24

• References & Citations :

  [1]Pengfei Xu, et al. Microglial TREM-1 receptor mediates neuroinflammatory injury via interaction with SYK in experimental ischemic stroke. Cell Death Dis. 2019 Jul 19;10 (8) :555.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported