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HZ-A-005

CAT: 0804-HY-147784Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-147784Size:1 Each
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Description
HZ-A-005 is a potent, selective, and covalent Bruton’s tyrosine kinase (BTK) inhibitor. HZ-A-005 markedly decreases tumor growth in xenograft mouse models[1].
CAS Number
[2041789-14-2]
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hz-a-005.html
Solubility
10 mM in DMSO
Smiles
C=C(C(N1CCC[C@@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5)=O)Cl
Molecular Formula
C25H23ClN6O2
Molecular Weight
474.94
References & Citations
[1]Huang W, et al. HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development. Bioorg Chem. 2020;105:104377.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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