HZ-A-005

• UNSPSC Description:

  HZ-A-005 is a potent, selective, and covalent Bruton’s tyrosine kinase (BTK) inhibitor. HZ-A-005 markedly decreases tumor growth in xenograft mouse models[1].

• Target Antigen:

  Btk

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hz-a-005.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C=C(C(N1CCC[C@@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5)=O)Cl

• Molecular Weight:

  474.94

• References & Citations:

  [1]Huang W, et al. HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development. Bioorg Chem. 2020;105:104377.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2041789-14-2