ONO-0300302

• Description :

  ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h) . ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1].

• Product Name Alternative :

  CGS 10746

• UNSPSC :

  12352005

• Target :

  LPL Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/ono-0300302.html

• Concentration :

  10mM

• Purity :

  98.02

• Solubility :

  DMSO : 220 mg/mL (ultrasonic)

• Smiles :

  O=C(O)CCC1=CN(C[C@H](CC2CC3=C(C=CC=C3)C2)[C@@H](C4=CC(OC)=C(C)C(OC)=C4)O)C=C1

• Molecular Formula :

  C29H35NO5

• Molecular Weight :

  477.59

• References & Citations :

  [1]Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8 (12) :1281-1286.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  LPAR1

• CAS Number :

  [856689-51-5]