ONO-0300302

CAT: 0804-HY-115450-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-115450-01Size:5 mg
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Description
ONO-0300302 is an orally active and potent LPA1 (lysophosphatidic acid receptor 1) antagonist, with an IC50 of 0.086 μM. ONO-0300302 is a slow tight binding inhibitor, and its binding affinity increases with time, with Kd of 0.34 nM (37 °C, 2 h) . ONO-0300302 can be used for benign prostatic hyperplasia (BPH) research[1].
CAS Number
[856689-51-5]
Product Name Alternative
CGS 10746
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/ono-0300302.html
Concentration
10mM
Purity
98.02
Solubility
DMSO : 220 mg/mL (ultrasonic)
Smiles
O=C(O)CCC1=CN(C[C@H](CC2CC3=C(C=CC=C3)C2)[C@@H](C4=CC(OC)=C(C)C(OC)=C4)O)C=C1
Molecular Formula
C29H35NO5
Molecular Weight
477.59
References & Citations
[1]Terakado M, et al. Discovery of a Slow Tight Binding LPA1 Antagonist (ONO-0300302) for the Treatment of Benign Prostatic Hyperplasia. ACS Med Chem Lett. 2017 Nov 20;8 (12) :1281-1286.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LPAR1

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