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BOS-318

CAT: 0804-HY-147140-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-147140-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BOS-318 is a potent, slowly dissociating, highly selective, and cell-permeable furin inhibitor with IC50 value of 1.9 nM. BOS-318 protects ENaC from subsequent activation by neutrophil elastase. BOS-318 can be used for the rsearch for CF lung disease[1][2].
CAS Number
2387633-15-8
UNSPSC
12352005
Target
Furin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/bos-318.html
Purity
98.45
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(O)CC1CCN(CC2=CC(C3=CC(Cl)=CC(Cl)=C3)=NC(OC4=CN=C(N5CCN(C)CC5)N=C4)=C2)CC1
Molecular Formula
C28H32Cl2N6O3
Molecular Weight
571.50
References & Citations
[1]Douglas LEJ, et al. A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease. Cell Chem Biol. 2022 Jun 16;29 (6) :947-957.e8. |[2]Nayak D, et al. Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy. Cell Chem Biol. 2022 Jun 16;29 (6) :927-929.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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