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Wee1/HDAC-IN-1

CAT: 0013-GTR19274680-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19274680-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Wee1/HDAC-IN-1 is a dual inhibitor targeting Wee1 and HDACs, exhibiting IC50 values of 1.2 nM for Wee1, 196 nM for HDAC1, 156 nM for HDAC3, and 55 nM for HDAC6. It shows potent antiproliferative activity against MV4-11 cells, with an IC50 of 0.076 μM. This compound selectively binds to the catalytic sites of Wee1 and HDACs, disrupting DNA damage repair pathways and inducing apoptosis in MV4-11 cells (apoptosis) . Wee1/HDAC-IN-1 is applicable for studying acute myeloid leukemia.
CAS Number
3037071-29-4
Smiles
O=C1C2=CN=C (N=C2N (C=3N=C (C=CC3) C (O) (C) C) N1CC=C) NC4=CC=C (C=C4) N5CCN (CC5) CCCCCCC (=O) NO
Molecular Formula
C33H43N9O4
Molecular Weight
629.77
Storage Conditions
-20°C
Notes
For research use only.

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