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HDAC/PSMD14-IN-1

CAT: 0013-GTR19257958-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257958-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC/PSMD14-IN-1 is a derivative of gambogic acid. It serves as an orally active dual inhibitor targeting PSMD14 and HDAC1, with IC50 values of 238.7 nM and 141.2 nM, respectively. The compound exhibits significant cytotoxicity against ESCC cell lines (IC50: 30-250 nM) and effectively reverses epithelial-mesenchymal transition (EMT) . Additionally, HDAC/PSMD14-IN-1 can induce apoptosis. In KYSE30 cell xenograft models in mice, it displays antitumor activity. HDAC/PSMD14-IN-1 is useful for researching esophageal cancer treatment.
CAS Number
3062141-62-9
Field of Research
Cell Biology, Epigenetics & Chromatin, Epigenetics & Chromatin; Cell Biology, Molecular Biology
Smiles
O=C1C (NC (=O) CCCCCCC (=O) NC=2C=CC=CC2N) =C3SSC=C3N1C
Molecular Formula
C20H24N4O3S2
Molecular Weight
432.56
Storage Conditions
-20°C
Notes
For research use only.

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