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MK-5108

CAT: 0013-GTR19164087-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164087-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-5108 (VX-689) is a potent, highly selective Aurora-A kinase inhibitor with IC50 of 0.064 nM, displays robust selectivity against Aurora-B (220-fold) and Aurora-C (190-fold) in the biochemical assays; also exhibits high selectivity for Aurora-A over a panel of 233 kinases, only one kinase (TrkA) with <100-fold selectivity; inhibits the growth of multiple human cancer cell lines in vitro and in human cancer xenograft models; MK-5108 significantly enhanced the efficacy of docetaxel without increasing its toxicity.Solid Tumors Phase 1 Clinical.
CAS Number
1010085-13-8
Product Name Alternative
MK 5108 | VX-689 | VX 689 | MK5108 | VX689
Purity
>98% (HPLC)
Solubility
DMSO: 6.4 mg/mL (Need Warming)
Smiles
OC (=O) [C@@]1 (CC2=CC=CC (NC3=NC=CS3) =N2) CC[C@@H] (CC1) OC1=C (F) C (Cl) =CC=C1 |r, c:7,13,16,26,30,32, t:5,11|
Molecular Formula
C22H21ClFN3O3S
Molecular Weight
461.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Cyclohexanecarboxylic acid, 4- (3-chloro-2-fluorophenoxy) -1-[[6- (2-thiazolylamino) -2-pyridinyl]methyl]-, trans-

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