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IITZ-02

CAT: 0013-GTR19273169-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273169-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IITZ-02 is a lysosomotropic autophagy inhibitor. It enhances autophagosome accumulation but inhibits autophagosome degradation by impairing lysosomal function, ultimately leading to autophagy suppression. IITZ-02 disrupts mitochondrial membrane potential and induces apoptosis through a mitochondria-mediated pathway. It shows potent anti-tumor activity in MDA-MB-231 xenograft mouse models and is applicable in cancer research.
CAS Number
1807988-46-0
Smiles
N=1C (=NC (=NC1NC=2C=CC (=CC2) C3=NC=4C=CC=CC4N3) N5CCOCC5) NC6=CC=C (OC) C=C6
Molecular Formula
C27H26N8O2
Molecular Weight
494.56
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N2-(4-(1H-Benzo[D]imidazol-2-YL)phenyl)-N4-(4-methoxyphenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
CAS Number1807988-46-0
PubChem CID177746435
IUPAC Name4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-methoxyphenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
Molecular FormulaC27H26N8O2
Molecular Weight494.5
XLogP5.1
Topological Polar Surface Area113
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count37
Formal Charge0
Complexity696
SMILES
COC1=CC=C(C=C1)NC2=NC(=NC(=N2)NC3=CC=C(C=C3)C4=NC5=CC=CC=C5N4)N6CCOCC6
InChI
InChI=1S/C27H26N8O2/c1-36-21-12-10-20(11-13-21)29-26-32-25(33-27(34-26)35-14-16-37-17-15-35)28-19-8-6-18(7-9-19)24-30-22-4-2-3-5-23(22)31-24/h2-13H,14-17H2,1H3,(H,30,31)(H2,28,29,32,33,34)
InChIKey
NVIHMOFJTWFABA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N2-(4-(1H-Benzo[D]imidazol-2-YL)phenyl)-N4-(4-methoxyphenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
CAS: 1807988-46-0
CID: 177746435
Formula: C27H26N8O2
MW: 494.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight494.5
XLogP35.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass494.21787210
Monoisotopic Mass494.21787210
Topological Polar Surface Area113 Ų
Heavy Atom Count37
Formal Charge0
Complexity696
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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