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IITZ-01

CAT: 0013-GTR19163450-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163450-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor, exhibits >10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than Chloroquine; enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy, also abolishes mitochondrial membrane potential and triggers apoptosis through the mitochondria-mediated pathway (TNBC cells IC50=1.54 uM, 48 h) ; displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model.
CAS Number
1807988-47-1
Product Name Alternative
Autophagy inhibitor IITZ-01
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL 310.87 mM; H2O : < 0.1 mg/mL
Smiles
FC1=CC=C (NC2=NC (N3CCOCC3) =NC (NC4=CC=C (C5=NC6=CC=CC=C6N5) C=C4) =N2) C=C1
Molecular Formula
C26H23FN8O
Molecular Weight
482.523
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N2- (4- (1H-benzo[d]imidazol-2-yl) phenyl) -N4- (4-fluorophenyl) -6-morpholino-1,3,5-triazine-2,4-diamine

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Alternative Products

CatalogName
BA2971-100IITZ-01
A20192-25IITZ-01 25mg
A20192-5IITZ-01 5mg
A20192-200IITZ-01 200mg
A20192-50IITZ-01 50mg
A20192-10IITZ-01 10mg
A20192-100IITZ-01 100mg
A20192-10mM-DIITZ-01 10mM * 1mL in DMSO

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