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IITZ-01

CAT: 0013-GTR19163450-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163450-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor, exhibits >10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than Chloroquine; enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy, also abolishes mitochondrial membrane potential and triggers apoptosis through the mitochondria-mediated pathway (TNBC cells IC50=1.54 uM, 48 h) ; displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model.
CAS Number
1807988-47-1
Product Name Alternative
Autophagy inhibitor IITZ-01
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL 310.87 mM; H2O : < 0.1 mg/mL
Smiles
FC1=CC=C (NC2=NC (N3CCOCC3) =NC (NC4=CC=C (C5=NC6=CC=CC=C6N5) C=C4) =N2) C=C1
Molecular Formula
C26H23FN8O
Molecular Weight
482.523
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N2- (4- (1H-benzo[d]imidazol-2-yl) phenyl) -N4- (4-fluorophenyl) -6-morpholino-1,3,5-triazine-2,4-diamine

Chemical Information

N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
CAS Number1807988-47-1
PubChem CID134817273
IUPAC Name4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine
Molecular FormulaC26H23FN8O
Molecular Weight482.5
XLogP5.2
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity683
SMILES
C1COCCN1C2=NC(=NC(=N2)NC3=CC=C(C=C3)F)NC4=CC=C(C=C4)C5=NC6=CC=CC=C6N5
InChI
InChI=1S/C26H23FN8O/c27-18-7-11-20(12-8-18)29-25-32-24(33-26(34-25)35-13-15-36-16-14-35)28-19-9-5-17(6-10-19)23-30-21-3-1-2-4-22(21)31-23/h1-12H,13-16H2,(H,30,31)(H2,28,29,32,33,34)
InChIKey
XGEDDGLPNSLBFE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
CAS: 1807988-47-1
CID: 134817273
Formula: C26H23FN8O
MW: 482.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight482.5
XLogP35.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count6
Exact Mass482.19788555
Monoisotopic Mass482.19788555
Topological Polar Surface Area104 Ų
Heavy Atom Count36
Formal Charge0
Complexity683
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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