RG-239

CAT: 0013-GTR19264171-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19264171-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly more potent than Betulinic acid (EC50= 1.04 μM) . It exhibits much higher selectivity for TGR5 over FXRα. The compound enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. Additionally, RG-239 inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 cells and microglia. RG-239 is applicable for research related to type 2 diabetes.

CAS Number

1199222-56-4

Field of Research

Pharmacology & Drug Discovery

Smiles

C (O) (=O) [C@]12[C@@] ([C@@]3 ([C@@] (C) (CC1) [C@@]4 (C) [C@] (CC3) ([C@]5 (C) [C@@] (CC4) (C (C) (C) [C@@] (CC=C) (O) CC5) [H]) [H]) [H]) ([C@H] (C (C) =C) CC2) [H]

Molecular Formula

C33H52O3

Molecular Weight

496.76

Storage Conditions

-20°C

Notes

For research use only.

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RG-239

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