RG-239

• Target:

  GPCR19

• Related Pathways:

  GPCR/G Protein

• Bioactivity:

  RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly more potent than Betulinic acid (EC50= 1.04 ?M) . It exhibits much higher selectivity for TGR5 over FXR?. The compound enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. Additionally, RG-239 inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 cells and microglia. RG-239 is applicable for research related to type 2 diabetes.

• Smiles:

  C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@](CC=C)(O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

• Molecular Formula:

  C33H52O3

• Molecular Weight:

  496.76

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1199222-56-4