RG-239

CAT: 0931-T211831-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T211831-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1199222-56-4

Target

GPCR19

Related Pathways

GPCR/G Protein

Bioactivity

RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly more potent than Betulinic acid (EC50= 1.04 μM) . It exhibits much higher selectivity for TGR5 over FXRα. The compound enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. Additionally, RG-239 inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 cells and microglia. RG-239 is applicable for research related to type 2 diabetes.

Smiles

C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@](CC=C)(O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]

Molecular Formula

C33H52O3

Molecular Weight

496.76

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-177050	RG-239
A1913-25	RG 108
BA4464-1	RG-12525
B6115-10	RG 13022
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464658-01	RG 7112
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sc-507292	RG-7112

RG-239

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