RG-239

CAT: 0931-MF-0118891-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0118891-01Size:10 mg
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CAS Number
1199222-56-4
Target
GPCR19
Related Pathways
GPCR/G Protein
Bioactivity
RG-239 is an orally active TGR5 agonist with an EC50 of 120 nM, significantly more potent than Betulinic acid (EC50= 1.04 ?M) . It exhibits much higher selectivity for TGR5 over FXR?. The compound enhances mitochondrial activity in adipocytes and promotes neurite outgrowth at higher concentrations. Additionally, RG-239 inhibits LPS-induced iNOS expression and nitrite production in Raw264.7 cells and microglia. RG-239 is applicable for research related to type 2 diabetes.
Smiles
C(O)(=O)[C@]12[C@@]([C@@]3([C@@](C)(CC1)[C@@]4(C)[C@](CC3)([C@]5(C)[C@@](CC4)(C(C)(C)[C@@](CC=C)(O)CC5)[H])[H])[H])([C@H](C(C)=C)CC2)[H]
Molecular Formula
C33H52O3
Molecular Weight
496.76
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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