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PROTAC HER2 degrader-1

CAT: 0013-GTR19263922-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263922-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACHER2 degrader-1 is a highly selective HER2 PROTAC degrader with a DC50 of 69 nM and a Dmax of 96%. It effectively inhibits HER2-positive cell proliferation and tumor growth by inducing sustained HER2 degradation and strongly inhibiting downstream pathways (AKT and ERK) . Additionally, PROTACHER2 degrader-1 can induce apoptosis in BT-474 cells and is useful for researching HER2-positive cancers.
CAS Number
2897640-93-4
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C1C2=CC=C (C=C2C (=O) N1C3C (=O) NC (=O) CC3) NCCCCCCCN4CCN (CC4) CCCOC5=CC6=NC=NC (NC7=CC=C (OC=8C=CN9N=CN=C9C8) C (=C7) C) =C6C=C5OC
Molecular Formula
C49H55N11O7
Molecular Weight
910.03
Storage Conditions
-20°C
Notes
For research use only.

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