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PRMT5-MTA-IN-4

CAT: 0013-GTR19263262-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263262-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRMT5-MTA-IN-4 (Compound 30) is a potent irreversible inhibitor of protein arginine methyltransferase 5 (PRMT5) with an IC50 of 8 nM. It obstructs arginine methylation, hinders ribosomal RNA processing, and suppresses cell cycle-related protein expression. This compound shows antiproliferative activity in various tumor cell lines, exemplified by an IC50 of 0.3 μM in DLD-1 cells. PRMT5-MTA-IN-4 holds potential for research into hematological malignancies such as acute myeloid leukemia and diffuse large B-cell lymphoma.
CAS Number
3025838-18-7
Field of Research
Epigenetics & Chromatin
Smiles
N#CC1=C (OC2 (C) CC2) C=C (Cl) C (F) =C1C3=C (C=NN3C) C=4C=C (C=C) C=5C (=O) NN=C (C5C4) CN
Molecular Formula
C26H22ClFN6O2
Molecular Weight
504.94
Storage Conditions
-20°C
Notes
For research use only.

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