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THR-β agonist 9

CAT: 0013-GTR19263218-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263218-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THR-β agonist 9 is a potent and selective THR-β activator, which shows sensitivity to His435 mutations with an EC50 of 3.2 nM. It demonstrates moderate selectivity, approximately 10-fold, and effectively activates various His435 mutants (H435A, H435Y, and H435R), with EC50 values ranging from 134.2 nM to 515.5 nM. THR-β agonist 9 presents potential for research into conditions such as dyslipidemia, metabolic syndrome-associated steatohepatitis (MASH), and resistance to thyroid hormone (RTH) .
CAS Number
2920045-74-3
Field of Research
Epigenetics & Chromatin, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (O) CNC (=O) C1=NC (OC) =C2C=C (OC=3C=CC=4C=CC=CC4C3) C=CC2=C1O
Molecular Formula
C23H18N2O6
Molecular Weight
418.40
Storage Conditions
-20°C
Notes
For research use only.

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