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PROTAC SGK3 degrader-2

CAT: 0013-GTR19264747-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264747-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACSGK3degrader-2 is the cis-diastereomer of PROTACSGK3degrader-1 (SGK3-PROTAC1), featuring a cis-hydroxy group in its VH032 section, which prevents binding to the VHL E3 ligase. This compound inhibits SGK3, SGK1, and S6K1 with IC50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but does not degrade SGK3. It serves as a control compound for studying the specific degradation effects mediated by SGK3-PROTAC1.
CAS Number
2381196-78-5
Field of Research
Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O (C[C@H]1CN (CCCCCCOCCOCCOCC (N[C@H] (C (=O) N2[C@H] (C (NCC3=CC=C (C=C3) C4=C (C) N=CS4) =O) C[C@H] (O) C2) C (C) (C) C) =O) CCO1) C=5N=C (N=C6C5C=NN6) C7=CC=C (NS (=O) (=O) C8=C (F) C=CC (C) =C8) C=C7
Molecular Formula
C57H73FN10O11S2
Molecular Weight
1157.38
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

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T212560-01PROTAC SGK3 degrader-2
HY-125878-01PROTAC SGK3 degrader-1
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A23922-1PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 1mg
A23922-5PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 5mg
A23922-10PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 10mg
HY-178803PROTAC BCL6 Degrader-2
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