DYB-03

• UNSPSC Description:

  DYB-03 is an oral active HIF-1α/EZH2 inhibitor. DYB-03 inhibits migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo. DYB-03 induces apoptosis in 2-ME2- and GSK126-resistant of A549 and H460 cells[1].

• Target Antigen:

  HIF/HIF Prolyl-Hydroxylase; Histone Methyltransferase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dyb-03.html

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  COC1=CC=C(/C=C/C(C2=CC=C(OC(C)(C)C=C3)C3=C2O)=O)C=C1OCCCN4CCOCC4

• Molecular Weight:

  479.56

• References & Citations:

  [1]Wang J, et al. The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy. Adv Sci (Weinh). 2024 Feb;11(7):e2303904.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  2982792-85-6