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DD-03-156

CAT: 0804-HY-137346-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-137346-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DD-03-156 is a potent and selective degrader of CDK17 and LIMK2. The selectivity and potency of DD-03-156 is exquisite and makes an advanced starting point for the development of a chemical probe for the degradation of CDK17 (Blue: VHL ligand , Black: linker HY-124380 (HY-124380); Pink: BRAF inhibitor (HY-14660) ).
CAS Number
2769753-69-5
Product Name Alternative
(S, R, S) -AHPC-Me-PEG2-dabrafenib
UNSPSC
12352005
Target
CDK; LIM Kinase (LIMK) ; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dd-03-156.html
Purity
99.90
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC(C)(C)C(S1)=NC(C2=CC=CC(NS(C3=C(F)C=CC=C3F)(=O)=O)=C2F)=C1C4=NC(NCCOCCOCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=NC=C4
Molecular Formula
C53H62F3N9O8S3
Molecular Weight
1106.31
References & Citations
[1] Donovan KA, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020;183 (6) :1714-1731.e10.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK17; LIMK2

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