XH-04

CAT: 0013-GTR19260002-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19260002-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

XH-04 (Lipid#4) is an ionizable lipid engineered for advanced mRNA delivery developed by JiaChen West Lake Biotech. Its core structure features a central benzene ring with asymmetric hydrophobic tails (C9-C10 chains) and pH-responsive tertiary amines that enable efficient mRNA encapsulation and endosomal escape. As detailed in CN113993839A, XH04 outperforms industry benchmarks (e.g., MC3 lipid), boosting protein expression by >10-fold in BHK cells. In PCT/CN2024/121624, JiaChen further demonstrated its utility in lung-targeted LNPs (tLNP/tLCNP) . When combined with cationic lipids (e.g., DOTMA at 2:1 molar ratio), XH 04 redirects >80% of mRNA delivery to murine lungs—overcoming liver tropism—while maintaining low toxicity. The lipid’s benzenic core and optimized alkyl chain geometry (patent claims 1-9) are credited for enhanced endosomal disruption and mRNA release kinetics. JiaChen’s innovations position XH-04 as a cornerstone for next-generation mRNA therapeutics.

Purity

>95%

Smiles

CCCCCCCCCOC (=O) CCCCCCCOC1=CC (COC (=O) CCCN (C) C) =C (OCCCCCCCC (=O) OCCCCCCCCC) C=C1

Molecular Formula

C47H83O8N

Molecular Weight

790.18

Notes

For research use only.

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