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DN-108

CAT: 0013-GTR19257718-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257718-02Size:10 mg
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Description
DN-108, a thiazolidinedione derivative, acts as an orally active peroxisome proliferator-activated receptor γ (PPARγ) agonist with antidiabetic properties. It improves hyperglycemia, hypertriglyceridemia, and hyperinsulinemia in diabetic mouse models. DN-108 enhances tissue glucose uptake (e.g., increases 2-deoxyglucose uptake in L6 muscle cells) and inhibits fatty acid synthase activity, making it a promising candidate for type 2 diabetes research.
CAS Number
195604-21-8
Field of Research
Metabolism Research, Molecular Biology
Smiles
O=C1SC (C (=O) N1) CC2=CC=C (C=C2) NC (=O) C3 (C=4C=CC=CC4) CC3
Molecular Formula
C20H18N2O3S
Molecular Weight
366.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

DN 108

RN & structure in first source

CAS Number195604-21-8
PubChem CID183791
IUPAC NameN-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenyl]-1-phenylcyclopropane-1-carboxamide
Molecular FormulaC20H18N2O3S
Molecular Weight366.4
XLogP3.2
Topological Polar Surface Area101
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity576
SMILES
C1CC1(C2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CC4C(=O)NC(=O)S4
InChI
InChI=1S/C20H18N2O3S/c23-17-16(26-19(25)22-17)12-13-6-8-15(9-7-13)21-18(24)20(10-11-20)14-4-2-1-3-5-14/h1-9,16H,10-12H2,(H,21,24)(H,22,23,25)
InChIKey
FTRMOJIRMFXZJV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of DN 108
CAS: 195604-21-8
CID: 183791
Formula: C20H18N2O3S
MW: 366.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.4
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass366.10381361
Monoisotopic Mass366.10381361
Topological Polar Surface Area101 Ų
Heavy Atom Count26
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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