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PROTAC BTK Degrader-12

CAT: 0013-GTR19250337-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19250337-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BTK Degrader-12 (EXAMPLE 19) is a heterobifunctional degrader that recruits the VHL E3 ligase (in blue) to BTK (in pink) via a linker (in black), inducing its proteasomal degradation. This tool compound is used in vitro and in vivo to study BTK-dependent signaling and its therapeutic targeting in oncology and immunology research.
CAS Number
2736508-65-7
Field of Research
Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CC=1C=C (C2=C3C (NC (=C3) C4=CC=C (C=N4) N5CCN (CC6CCN (CC6) C7=CC=C (C=C7) N8C (=O) NC (=O) CC8) CC5) =NC=N2) C=CC1[C@H] (NC (=O) C9=NC (C (C) (C) C) =NO9) C
Molecular Formula
C47H54N12O4
Molecular Weight
851.01
Storage Conditions
-20°C
Notes
For research use only.

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