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CCR6 antagonist 2

CAT: 0013-GTR19249594-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249594-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Compound 20c is a potent and selective CCR6 antagonist with a binding affinity (Ki) of 1.1 nM. It effectively blocks CCL20-induced calcium mobilization (IC50 = 4.9 nM) and inhibits the chemotaxis of CCR6-expressing T cells (IC50 = 190 nM) . This tool compound is useful for studying CCR6-mediated immune responses in autoimmune and inflammatory disease models, both in vitro and in vivo.
Field of Research
Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery, Infectious Disease & Virology, Pharmacology & Drug Discovery
Molecular Formula
C19H24N4O4
Molecular Weight
372.42
Storage Conditions
-20°C
Notes
For research use only.

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