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CCR4 antagonist 2

CAT: 0013-GTR19206302-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19206302-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCR4 antagonist 2 (Compound 31) is a potent, orally active small molecule inhibitor of CCR4. It selectively blocks Treg migration into tumors, as shown in in vivo models, while sparing peripheral Tregs, and exhibits IC50 values of 40 nM and 70 nM in calcium flux and chemotaxis assays, respectively. This makes it a valuable research tool for immuno-oncology studies.
CAS Number
2206788-99-8
Field of Research
Immunology & Inflammation, Immunology & Inflammation; Pharmacology & Drug Discovery, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery
Smiles
[C@H] (C) (N1C=2C (C (C#N) =N1) =NC=C (N2) C=3C[C@@H] (C) [C@H] (CC3) N4[C@H] (CO) CCC4) C5=C (Cl) C=C (Cl) C=C5
Molecular Formula
C26H28Cl2N6O
Molecular Weight
511.45
Storage Conditions
-20°C
Notes
For research use only.

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