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CCR6 antagonist 3

CAT: 0804-HY-176979Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176979Size:1 Each
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Description
CCR6 antagonist 3 (compound OXM2) is a potent and selective CC chemokine receptor 6 (CCR6) allosteric antagonist (IC50 = 166 nM) . CCR6 antagonist 3 binds to an extracellular pocket and disrupts the receptor activation network. CCR6 antagonist 3 can be used for chronic inflammatory diseases research[1].
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NC[C@H](CN1C23CC(C3)C2)OCC1=O)C4(CC4)C5=CC=C(C(F)(F)F)C=C5
Molecular Formula
C21H23F3N2O3
Molecular Weight
408.41
References & Citations
[1]Wasilko DJ, et al. Structural basis for CCR6 modulation by allosteric antagonists. Nat Commun. 2024 Aug 31;15 (1) :7574.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR6

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