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PHD2-IN-4

CAT: 0013-GTR19249219-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19249219-02Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHD2-IN-4 (compound 1) is a potent, nanomolar-range PHD2 inhibitor (IC50 = 4 nM) . It is a valuable research tool for investigating hypoxia signaling pathways and has been utilized in preclinical studies related to chronic kidney disease and anemia.
CAS Number
2924181-60-0
Field of Research
Epigenetics & Chromatin, Metabolism Research
Smiles
N#CC1=CC=C (C=C1) CNC (=O) C2=NC=C3N=C (C=CC3=C2O) N4CCOCC4
Molecular Formula
C21H19N5O3
Molecular Weight
389.407
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N-[(4-cyanophenyl)methyl]-5-hydroxy-2-morpholin-4-yl-1,7-naphthyridine-6-carboxamide
CAS Number2924181-60-0
PubChem CID168817517
IUPAC NameN-[(4-cyanophenyl)methyl]-5-hydroxy-2-morpholin-4-yl-1,7-naphthyridine-6-carboxamide
Molecular FormulaC21H19N5O3
Molecular Weight389.4
XLogP2.2
Topological Polar Surface Area111
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count29
Formal Charge0
Complexity609
SMILES
C1COCCN1C2=NC3=CN=C(C(=C3C=C2)O)C(=O)NCC4=CC=C(C=C4)C#N
InChI
InChI=1S/C21H19N5O3/c22-11-14-1-3-15(4-2-14)12-24-21(28)19-20(27)16-5-6-18(25-17(16)13-23-19)26-7-9-29-10-8-26/h1-6,13,27H,7-10,12H2,(H,24,28)
InChIKey
LFPWGXGGSSZTIU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-[(4-cyanophenyl)methyl]-5-hydroxy-2-morpholin-4-yl-1,7-naphthyridine-6-carboxamide
CAS: 2924181-60-0
CID: 168817517
Formula: C21H19N5O3
MW: 389.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight389.4
XLogP32.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass389.14878949
Monoisotopic Mass389.14878949
Topological Polar Surface Area111 Ų
Heavy Atom Count29
Formal Charge0
Complexity609
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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