9(R)-HODE

9(R)-HODE

• CAS Number: 10075-11-3
• UNSPSC Description: 9(R)-HODE (9(R)-Hydroxyoctadecadienoic acid) is a monohydroxy fatty acid and metabolite of linoleic acid. It is formed from linoleic acid by COX and lipoxygenase (LO).9(R)-HODE induces chemotaxis, increases the levels of chemokine (C-C motif) receptor 9 (CCR9) and chemokine (C-X-C motif) receptor 4 (CXCR4), and inhibits IL-6 release in primary human monocytes. It inhibits CD3α- and CD28-induced proliferation of isolated human peripheral blood lymphocytes when used at a concentration of 25 μg/mL.
• Target Antigen: Endogenous Metabolite
• Type: Natural Products
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/9-r-hode.html
• Smiles: CCCCC/C=C\C=C\[C@H](O)CCCCCCCC(O)=O
• Molecular Weight: 296.44
• References & Citations: [1]Camacho, et al. Interleukin-1 enhances the ability of cultured human umbilical vein endothelial cells to oxidize linoleic acid. J. Biol. Chem. 270(29), 17279-17286 (1995).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported