9(S)-HODE-13C18

9(S)-HODE-13C18

• UNSPSC Description: 9(S)-HODE-13C18 ((+)-α-Dimophecolic acid-13C18) is 13C labeled 9S-HODE. 9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO[1][2].
• Target Antigen: Apoptosis; Endogenous Metabolite; Isotope-Labeled Compounds
• Type: Isotope-Labeled Compounds
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease;Others
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/9-s-hode-13c18.html
• Smiles: O[13C]([13CH2][13CH2][13CH2][13CH2][13CH2][13CH2][13CH2][13C@@H](/[13CH]=[13CH]/[13CH]=[13CH]\[13CH2][13CH2][13CH2][13CH2][13CH3])O)=O
• Molecular Weight: 314.31
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Liu S, et al. Linoleic acid derivatives target miR-361-3p/BTG2 to confer anticancer effects in acute myeloid leukemia. J Biochem Mol Toxicol. 2023 Nov;37(11):e23481.|[3]Spiteller P, et al. 9-Hydroxy-10, 12-octadecadienoic acid (9-HODE) and 13-hydroxy-9, 11-octadecadienoic acid (13-HODE): excellent markers for lipid peroxidation[J]. Chemistry and Physics of Lipids, 1997, 89(2): 131-139.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported