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SKF 83822

CAT: 0804-HY-116874-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116874-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC) . SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia[1][2].
CAS Number
74115-08-5
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335, H400
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf-83822.html
Purity
98.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(C=C2C(CN(CCC2=C1Cl)CC=C)C3=CC=CC(C)=C3)O
Molecular Formula
C20H22ClNO2
Molecular Weight
343.85
Precautions
H301, H315, H319, H335, H400
References & Citations
[1]Wirtshafter D. Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822. Pharmacol Biochem Behav. 2007 Mar;86 (3) :505-10. |[2]Peacock L, et al. Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol Psychiatry. 2001 Oct 1;50 (7) :501-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor

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