SKF 83959

CAT: 0804-HY-130344-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-130344-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ) -1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression[1][2][3][4].
CAS Number
[80751-85-5]
UNSPSC
12352005
Target
Dopamine Receptor; Sigma Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/skf83959.html
Purity
98.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC1=C(O)C=C2C(C3=CC=CC(C)=C3)CN(C)CCC2=C1Cl
Molecular Formula
C18H20ClNO2
Molecular Weight
317.81
References & Citations
[1] Sheng G, et al. SKF83959 Has Protective Effects in the Scopolamine Model of Dementia. Biol Pharm Bull. 2018;41 (3) :427-434.|[2]Jin LQ, et al. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain. J Neurochem. 2003;85 (2) :378-386.|[3]Neumeyer JL, et al. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines. Eur J Pharmacol. 2003;474 (2-3) :137-140.|[4]Guo L, et al. SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol Pharmacol. 2013;83 (3) :577-586.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor; D2 Receptor; D3 Receptor; D5 Receptor; Sigma 1 Receptor

Related Products

CatalogName
HY-125942SKF-96365
HY-105480SKF 104351
HY-171471SKF 10810
HY-103430A-01SKF-83566
HY-100915SKF 97541
HY-19044SKF 95601
HY-100228SKF 89976A
HY-12511-01SKF-86002
HY-P3066-01SKF 100398
HY-111160SKF 83509

Alternative Products

CatalogName
466159-01SKF 83959
B6937-50SKF 83959 hydrobromide
532747SKF-83959 HBr
TR301555Sodium bicarbonate transporter like protein 11 (SLC4A11) Human shRNA Plasmid Kit (Locus ID 83959)
SR313298Sodium bicarbonate transporter like protein 11 (SLC4A11) Human siRNA Oligo Duplex (Locus ID 83959)
TL301555VSodium bicarbonate transporter like protein 11 (SLC4A11) Human shRNA Lentiviral Particle (Locus ID 83959)

Popular Products