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SKF-96365

CAT: 0804-HY-125942Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-125942Size:1 Each
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Description
SKF-96365 is a blocker of calcium store-operated calcium influx (SOCE) and transient receptor potential channels (TRPC) . SKF-96365 reduces the increase in intracellular calcium concentration by blocking TRPC channels and SOCE. SKF-96365 enhances the reverse operation of Na⁺/Ca²⁺ exchanger (NCX) (Ca²⁺ influx) in glioblastoma, leading to intracellular calcium overload and cytotoxicity. SKF-96365 inhibits the CaMKIIγ/AKT pathway and simultaneously induces apoptosis and cell protective autophagy in colorectal cancer cells. SKF-96365 can be used in calcium signaling and cancer research[1][2][3][4].
CAS Number
162849-90-3
UNSPSC
12352005
Target
Akt; Apoptosis; Autophagy; Calcium Channel; CaMK; CRAC Channel; Na+/Ca2+ Exchanger; TRP Channel
Related Pathways
Apoptosis; Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling; PI3K/Akt/mTOR
Field of Research
Cancer; Neurological Disease
Smiles
COC1=CC=C(CCCOC(C2=CC=C(OC)C=C2)CN3C=CN=C3)C=C1
Molecular Formula
C22H26N2O3
Molecular Weight
366.45
References & Citations
[1]Jing Z, et al. SKF-96365 activates cytoprotective autophagy to delay apoptosis in colorectal cancer cells through inhibition of the calcium/CaMKIIγ/AKT-mediated pathway. Cancer Lett. 2016 Mar 28;372 (2) :226-38. |[2]Song M, Chen D, Yu SP. The TRPC channel blocker SKF 96365 inhibits glioblastoma cell growth by enhancing reverse mode of the Na (+) /Ca (2+) exchanger and increasing intracellular Ca (2+) . Br J Pharmacol. 2014 Jul;171 (14) :3432-47|[3]Chen T, et al. Protective effects of SKF-96365, a non-specific inhibitor of SOCE, against MPP+-induced cytotoxicity in PC12 cells: potential role of Homer1. PLoS One. 2013 Jan 31;8 (1) :e55601.|[4]Rae MG, Hilton J, Sharkey J. Putative TRP channel antagonists, SKF 96365, flufenamic acid and 2-APB, are non-competitive antagonists at recombinant human α1β2γ2 GABA (A) receptors. Neurochem Int. 2012 May;60 (6) :543-54.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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SIH-305-5MGSKF-96365
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A16706-100SKF-96365 hydrochloride 100mg
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A16706-25SKF-96365 hydrochloride 25mg
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