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TK-129

CAT: 0013-GTR19240132-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240132-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK-129 is an orally active, low-toxicity, potent KDM5B inhibitor (with high affinity; IC50=44 nM) . TK-129 exerts cardioprotective effects by inhibiting KDM5B and blocking the KDM5B-associated Wnt pathway. TK-129 reduces ang II-induced activation of cardiac fibroblasts in vitro and reduces isoprenaline-induced myocardial remodelling and fibrosis in vivo. TK-129 can be used in studies of cardiovascular disease.
CAS Number
3031476-73-7
Purity
>98%
Smiles
O=C (N[C@H]1CN (C (C2=NNC (C (C) C) =C2) =O) CC1) NC3CC3
Molecular Formula
C15H23N5O2
Molecular Weight
305.38
Notes
For research use only.

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