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HS-345

CAT: 0013-GTR19239139-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239139-02Size:50 mg
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Description
HS-345 is a potent TrkA/Akt pathway inhibitor for pancreatic cancer research, demonstrating anti-proliferative and pro-apoptotic effects in vitro. It also exhibits anti-angiogenic activity by suppressing HIF-1α/VEGF expression, supporting its investigation in both cellular and animal models of pancreatic cancer.
CAS Number
1462329-41-4
Field of Research
Signal Transduction
Smiles
O=S (=O) (C=1C=C (C=NC1N) C2=CN=C3NC=C (C=4C=CN=CC4) C3=C2) N (C) C
Molecular Formula
C19H18N6O2S
Molecular Weight
394.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-amino-N,N-dimethyl-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-sulfonamide
CAS Number1462329-41-4
PubChem CID71812242
IUPAC Name2-amino-N,N-dimethyl-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-sulfonamide
Molecular FormulaC19H18N6O2S
Molecular Weight394.5
XLogP1.8
Topological Polar Surface Area126
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity633
SMILES
CN(C)S(=O)(=O)C1=C(N=CC(=C1)C2=CC3=C(NC=C3C4=CC=NC=C4)N=C2)N
InChI
InChI=1S/C19H18N6O2S/c1-25(2)28(26,27)17-8-14(9-22-18(17)20)13-7-15-16(11-24-19(15)23-10-13)12-3-5-21-6-4-12/h3-11H,1-2H3,(H2,20,22)(H,23,24)
InChIKey
LKKJGBNHOXRBGF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-amino-N,N-dimethyl-5-(3-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyridine-3-sulfonamide
CAS: 1462329-41-4
CID: 71812242
Formula: C19H18N6O2S
MW: 394.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight394.5
XLogP31.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass394.12119501
Monoisotopic Mass394.12119501
Topological Polar Surface Area126 Ų
Heavy Atom Count28
Formal Charge0
Complexity633
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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