ETC-168

CAT: 0013-GTR19235391-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19235391-02Size:50 mg

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Description

ETC-168 is a potent and selective oral inhibitor of MNK1 (IC50=23 nM) and MNK2 (IC50=43 nM) . It exhibits antiproliferative activity in cellular assays and has demonstrated efficacy in animal models, supporting its use in oncology research targeting mRNA translation and cancer cell proliferation.

CAS Number

1464150-99-9

Field of Research

Signal Transduction

Smiles

C (#N) C1=CC=C (C=2N3C (=NC2) C=CC (=N3) C4=CC=C (C (=O) N5CCOCC5) C=C4) C=C1

Molecular Formula

C24H19N5O2

Molecular Weight

409.44

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

4-(6-(4-(Morpholine-4-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile

CAS Number	1464150-99-9
PubChem CID	71744719
IUPAC Name	4-[6-[4-(morpholine-4-carbonyl)phenyl]imidazo[1,2-b]pyridazin-3-yl]benzonitrile
Molecular Formula	C24H19N5O2
Molecular Weight	409.4
XLogP	2.5
Topological Polar Surface Area	83.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	31
Formal Charge	0
Complexity	671

SMILES

C1COCCN1C(=O)C2=CC=C(C=C2)C3=NN4C(=NC=C4C5=CC=C(C=C5)C#N)C=C3

InChI

InChI=1S/C24H19N5O2/c25-15-17-1-3-19(4-2-17)22-16-26-23-10-9-21(27-29(22)23)18-5-7-20(8-6-18)24(30)28-11-13-31-14-12-28/h1-10,16H,11-14H2

InChIKey

CARBAQLLNJEQRM-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 1464150-99-9

CID: 71744719

Formula: C24H19N5O2

MW: 409.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	409.4
XLogP3	2.5
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	409.15387487
Monoisotopic Mass	409.15387487
Topological Polar Surface Area	83.5 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	671
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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ETC-168

Chemical Information

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