KT-474

CAT: 0013-GTR19221258-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19221258-01Size:1 mg

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Description

KT-474 (KYM-001) is a PROTAC molecule designed to degrade IRAK4, a key kinase in innate immune signaling. Its application is primarily in preclinical research for autoimmune, inflammatory, and oncological diseases, with studies demonstrating its activity in both cellular assays and animal models of inflammation.

CAS Number

2432994-31-3

Product Name Alternative

KYM001, KYM-001, KT474, PROTAC, PROTAC IRAK4 degrader-7

Field of Research

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery, Signal Transduction

Purity

98.50% (May vary between batches)

Solubility

10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (3.81 mM) ; DMSO:80 mg/mL (92.39 mM)

Smiles

O=C1N (C=2C (=C (C#CCOC3CCN (C[C@H]4CC[C@@H] (CC4) N5C=C (NC (=O) C6=C7N (N=C6) C=CC (=N7) N8[C@@]9 (C[C@] (C8) (OC9) [H]) [H]) C (C (F) F) =N5) CC3) C=CC2) N1C) C%10C (=O) NC (=O) CC%10

Molecular Formula

C44H49F2N11O6

Molecular Weight

865.93

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

PROTAC IRAK4 degrader-7

See also: KT-474 (annotation moved to).

CAS Number	2432994-31-3
PubChem CID	146599824
IUPAC Name	N-[3-(difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide
Molecular Formula	C44H49F2N11O6
Molecular Weight	865.9
XLogP	2.5
Topological Polar Surface Area	172
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	11
Heavy Atom Count	63
Formal Charge	0
Complexity	1790

SMILES

CN1C2=C(C=CC=C2N(C1=O)C3CCC(=O)NC3=O)C#CCOC4CCN(CC4)CC5CCC(CC5)N6C=C(C(=N6)C(F)F)NC(=O)C7=C8N=C(C=CN8N=C7)N9C[C@H]1C[C@@H]9CO1

InChI

InChI=1S/C44H49F2N11O6/c1-52-39-27(4-2-6-34(39)57(44(52)61)35-11-12-37(58)50-43(35)60)5-3-19-62-30-13-16-53(17-14-30)22-26-7-9-28(10-8-26)56-24-33(38(51-56)40(45)46)48-42(59)32-21-47-55-18-15-36(49-41(32)55)54-23-31-20-29(54)25-63-31/h2,4,6,15,18,21,24,26,28-31,35,40H,7-14,16-17,19-20,22-23,25H2,1H3,(H,48,59)(H,50,58,60)/t26?,28?,29-,31-,35?/m1/s1

InChIKey

NQGKNAVUMAHSQN-PKIOHZLWSA-N

Chemical Structure

2D Structure

CAS: 2432994-31-3

CID: 146599824

Formula: C44H49F2N11O6

MW: 865.9

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	865.9
XLogP3	2.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	11
Exact Mass	865.38353465
Monoisotopic Mass	865.38353465
Topological Polar Surface Area	172 Å²
Heavy Atom Count	63
Formal Charge	0
Complexity	1790
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

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GTR19161934-01	ZSTK-474
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GTR19203700-01	KT-5823
GTR19233855-01	KT-333
GTR19194097-01	KT 1
GTR19203701-01	KT-5720
GTR19250347-01	KT-253
GTR19239274-01	KT D606
GTR19236630	KT-333
GTR19231426-01	KT-531

Alternative Products

Catalog	Name
BUP21029-01	KT-474
C01784-25mg	KT 474
A23929-10	KT-474 10mg
A23929-5	KT-474 5mg
A23929-1	KT-474 1mg
BI12247-01	KT-474 (hydrochloride)
A23929-50	KT-474 50mg
B6673-.025	KT 5823
T200088-01	KT D606
453071-01	KT 5720

KT-474

Chemical Information

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