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HDAC6 degrader-3

CAT: 0013-GTR19220711-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19220711-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6 degrader-3 is a potent and selective degrader of HDAC6, achieving degradation via ternary complex formation and the ubiquitin-proteasome system with a DC50 of 19.4 nM. It induces strong α-tubulin hyperacetylation and is a valuable chemical probe for studying HDAC6 biology in cellular and in vivo models of cancer and neurodegenerative diseases.
CAS Number
2785404-83-1
Field of Research
Epigenetics & Chromatin, Molecular Biology, Pharmacology & Drug Discovery
Smiles
C (C (O) =O) (F) (F) F.O=C1C=2C (C (=O) N1C3C (=O) NC (=O) CC3) =CC=CC2OCC (NCCCCCCCC (NC=4C=C5C (=CC4) N (CC6=C (F) C=C (C (NO) =O) C=C6) C (C) =N5) =O) =O
Molecular Formula
C41H41F4N7O11
Molecular Weight
883.8
Storage Conditions
-20°C
Notes
For research use only.

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