Products for Research Use Only
RegisterLogin

GS-443902

CAT: 0013-GTR19222018-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19222018-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GS-443902, the active triphosphate metabolite of Remdesivir, is a potent viral RNA-dependent RNA polymerase (RdRp) inhibitor. It demonstrates in vitro activity against viruses like RSV and HCV with IC50 values of 1.1 μM and 5 μM, respectively, supporting antiviral research in biochemical and cell-based assays.
CAS Number
1355149-45-9
Field of Research
Cell Biology, Infectious Disease & Virology, Metabolism Research, Molecular Biology, Protein Biochemistry
Smiles
Nc1ncnn2c (ccc12) [C@@]1 (O[C@H] (COP (O) (=O) OP (O) (=O) OP (O) (O) =O) [C@@H] (O) [C@H]1O) C#N
Molecular Formula
C12H16N5O13P3
Molecular Weight
531.2
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

GS-441524 triphosphate

GS-443902 is an organic triphosphate that is GS-441524 in which the 5'-hydroxy group has been replaced by a triphosphate group. It is the active metabolite of remdesivir. It has a role as an anticoronaviral agent, an antiviral drug and a drug metabolite. It is a nitrile, an aromatic amine, a C-nucleoside, an organic triphosphate and a pyrrolotriazine. It is functionally related to a GS-441524.

CAS Number1355149-45-9
PubChem CID56832906
IUPAC Name[[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Molecular FormulaC12H16N5O13P3
Molecular Weight531.20
XLogP-5.3
Topological Polar Surface Area290
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count17
Rotatable Bond Count8
Heavy Atom Count33
Formal Charge0
Complexity941
SMILES
C1=C2C(=NC=NN2C(=C1)[C@]3([C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)C#N)N
InChI
InChI=1S/C12H16N5O13P3/c13-4-12(8-2-1-6-11(14)15-5-16-17(6)8)10(19)9(18)7(28-12)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h1-2,5,7,9-10,18-19H,3H2,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t7-,9-,10-,12+/m1/s1
InChIKey
DFVPCNAMNAPBCX-LTGWCKQJSA-N
Chemical Structure
2D Structure
2D structure of GS-441524 triphosphate
CAS: 1355149-45-9
CID: 56832906
Formula: C12H16N5O13P3
MW: 531.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight531.20
XLogP3-5.3
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count17
Rotatable Bond Count8
Exact Mass530.99574658
Monoisotopic Mass530.99574658
Topological Polar Surface Area290 Ų
Heavy Atom Count33
Formal Charge0
Complexity941
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19224723-01GS-566500
GTR19208544-01GS-9256
GTR19201267-01GS 39783
GTR19198312-01GS-462808
GTR19198301-01GS-6620
GTR19190306-01GS-704277
GTR19263542-01GS​​K2181306A
GTR19263042-01GS-1427
GTR19259567GS-680
GTR19203820-01GS-9901

Alternative Products

CatalogName
T5539-01GS-443902
HY-126303C-01GS-443902 (trisodium)
FEC05021Gs-443902 trisodium
AR-R10628-01Remdesivir Metabolite GS-443902
MBS131349Selonsertib (GS-4997; GS4997; GS 4997)
sc-490337CGS 9973
BA2269-10GS-621763
B8461-25GS-441524
B8021-5.1GS-7340
BA4730-10GS-626510

Popular Products