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GS-444217

CAT: 0013-GTR19164145-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164145-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GS-444217 (GS444217) is a potent, selective, ATP-competitive, orally available inhibitor of ASK1 with Kd/IC50 of 4.1/2.87 nM; displays >53-fold selectivity over DYRK1A and 104-fold over RSK4 in a panel of 442 kinases; strongly suppresses the activation of ASK1, p38, and JNK in the kidney resulting in decreased death of parenchymal cells, inflammation, and fibrosis; abrogates p38 MAPK activation in diabetic kidneys but has no effect upon hypertension in Nos3 (-/-) mice; dose dependently reduced pulmonary arterial pressure and reduced RV hypertrophy in pulmonary arterial hypertension (PAH) models; also reduces the progressive inflammation and fibrosis in the kidney and halted decline of glomerular filtration rate in models of kidney disease, causes regression of fibrosis combined with RAS inhibitor enalapril.
CAS Number
1262041-49-5
Product Name Alternative
GS444217
Purity
>98% (HPLC)
Solubility
DMSO: 13 mg/mL (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
O=C (NC1=CC=CC (C2=NN=CN2C3CC3) =C1) C4=NC=CC (N5C=C (C6CC6) N=C5) =C4
Molecular Formula
C23H21N7O
Molecular Weight
411.469
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (4-cyclopropyl-1H-imidazol-1-yl) -N- (3- (4-cyclopropyl-4H-1,2,4-triazol-3-yl) phenyl) picolinamide

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Alternative Products

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MBS3844962-01GS-444217
A20517-100GS-444217 100mg
A20517-50GS-444217 50mg
A20517-25GS-444217 25mg
A20517-10GS-444217 10mg
A20517-1GS-444217 1mg
HY-100844RGS-444217 (Standard)
A20517-5GS-444217 5mg
A20517-10mM-DGS-444217 10mM * 1mL in DMSO
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