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L-97-1

CAT: 0804-HY-136702Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-136702Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L-97-1 is a A1 adenosine receptor (A1AR) antagonist. L-97-1 is a water-soluble small molecule compound with high affinity and high selectivity against human A1 adenosine receptors. L-97-1 works by blocking A1 adenosine receptors. In patients with asthma, adenosine is an important signaling molecule capable of causing bronchoconstriction by activating A1AR. L-97-1 reduces airway hyperreactivity (BHR) by competitively binding to A1AR, thereby alleviating or blocking adenosine-induced bronchoconstriction and inflammation[1].
CAS Number
770703-20-3
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-97-1.html
Smiles
O=C(N1CCC)N(CCC2=CC=C(N)C=C2)C3=C(N(CCN(CC)CCO)C(CC4=CC=CC=C4)=N3)C1=O
Molecular Formula
C29H38N6O3
Molecular Weight
518.65
References & Citations
[1]Obiefuna P C M, et al. A novel A1 adenosine receptor antagonist, L-97-1 [3-[2- (4-aminophenyl) -ethyl]-8-benzyl-7-{2-ethyl- (2-hydroxy-ethyl) -amino]-ethyl}-1-propyl-3, 7-dihydro-purine-2, 6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma[J]. Journal of Pharmacology and Experimental Therapeutics, 2005, 315 (1) : 329-336.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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