TP-110

CAT: 0013-GTR19211074-02Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19211074-02Size:50 mg

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Description

TP-110 is a novel proteasome inhibitor that potently inhibits tumor cell growth and induces apoptosis, as demonstrated in RPMI8226 multiple myeloma cells. It functions by reducing levels of IAP proteins such as cIAP-1 and XIAP, thereby promoting caspase activation. This mechanism supports its research application in studying hematological cancers and apoptosis pathways in vitro.

CAS Number

688737-95-3

Smiles

C (C (N[C@@H] (CC1=CC=C (OC) C=C1) C (N[C@H] (C (NC (CC2=CC=C (OC) C=C2) C=O) =O) C (C) C) =O) =O) C=3C4=C (C=CC3) C=CC=C4

Molecular Formula

C37H41N3O6

Molecular Weight

623.74

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

TP-110

CAS Number	688737-95-3
PubChem CID	11592579
IUPAC Name	(2S)-2-[[(2S)-3-(4-methoxyphenyl)-2-[(2-naphthalen-1-ylacetyl)amino]propanoyl]amino]-N-[1-(4-methoxyphenyl)-3-oxopropan-2-yl]-3-methylbutanamide
Molecular Formula	C37H41N3O6
Molecular Weight	623.7
XLogP	5.9
Topological Polar Surface Area	123
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Heavy Atom Count	46
Formal Charge	0
Complexity	974

SMILES

CC(C)[C@@H](C(=O)NC(CC1=CC=C(C=C1)OC)C=O)NC(=O)[C@H](CC2=CC=C(C=C2)OC)NC(=O)CC3=CC=CC4=CC=CC=C43

InChI

InChI=1S/C37H41N3O6/c1-24(2)35(37(44)38-29(23-41)20-25-12-16-30(45-3)17-13-25)40-36(43)33(21-26-14-18-31(46-4)19-15-26)39-34(42)22-28-10-7-9-27-8-5-6-11-32(27)28/h5-19,23-24,29,33,35H,20-22H2,1-4H3,(H,38,44)(H,39,42)(H,40,43)/t29?,33-,35-/m0/s1

InChIKey

IJDYUMDIJFFMQQ-ROSKKCPQSA-N

Chemical Structure

2D Structure

CAS: 688737-95-3

CID: 11592579

Formula: C37H41N3O6

MW: 623.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	623.7
XLogP3	5.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	15
Exact Mass	623.29953604
Monoisotopic Mass	623.29953604
Topological Polar Surface Area	123 Å²
Heavy Atom Count	46
Formal Charge	0
Complexity	974
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T68869-01	TP-110
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HY-119127	TP-680
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TP-110

Chemical Information

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