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MSN-125

CAT: 0804-HY-120079-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120079-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MSN-125 is a potent Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochondrial outer membrane permeabilization (MOMP) with an IC50 of 4 μM. MSN-125 potently inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons, protects primary neurons against glutamate excitotoxicity[1].
CAS Number
1592908-16-1
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/msn-125.html
Purity
99.00
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N(CC3=CC=C(C=C3)Br)[C@@H]4[C@H](OC5=CC(OCOCCOC)=CC=C45)CN)=O
Molecular Formula
C36H38BrN3O6
Molecular Weight
688.61
References & Citations
[1]Niu X, et al. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017 Apr 20;24 (4) :493-506.e5.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bak; Bax

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