NBD-125

• Description :

  NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

• UNSPSC :

  12352005

• Target :

  RAR/RXR

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nbd-125.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=C2C=[N+](CCC3=C4C=CC(OC)=C3)C4=CC2=CC=C1.[Cl-]

• Molecular Formula :

  C19H18ClNO2

• Molecular Weight :

  327.80

• References & Citations :

  [1]Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63 (11) :5841-5855.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2367641-24-3]