NBD-125

• UNSPSC Description:

  NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

• Target Antigen:

  RAR/RXR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nbd-125.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C2C=[N+](CCC3=C4C=CC(OC)=C3)C4=CC2=CC=C1.[Cl-]

• Molecular Weight:

  327.80

• References & Citations:

  [1]Beibei Xu, et al. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer. J Med Chem. 2020 Jun 11;63(11):5841-5855.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2367641-24-3