BRD3 (BD1+BD2), GST-tag Recombinant

• Description:

  BRD3 (BD1+BD2), GST-tag Recombinant_x000D_ Catalog number: B2019122_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 μg_x000D_ Molecular Weight or Concentration: 70 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: Bromodomain containing 3, BRD3, RING3L, BRD-3_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021102118._x000D_ 2: Sheppard GS, Wang L, Fidanze SD, Hasvold LA, Liu D, Pratt JK, Park CH, Longenecker K, Qiu W, Torrent M, Kovar PJ, Bui M, Faivre E, Huang X, Lin X, Wilcox D, Zhang L, Shen Y, Albert DH, Magoc TJ, Rajaraman G, Kati WM, McDaniel KF. Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain J Med Chem. 2020 May 28;63(10):5585-5623._x000D_ 3: Chiang CM. Nonequivalent response to bromodomain-targeting BET inhibitors in oligodendrocyte cell fate decision Chem Biol. 2014 Jul 17;21(7):804-6._x000D_ 4: Zhang M, Wang B, Urabe G, Huang Y, Plutzky J, Kent KC, Guo LW. The BD2 domain of BRD4 is a determinant in EndoMT and vein graft neointima formation Cell Signal. 2019 Sep;61:20-29._x000D_ 5: Shi M, He J, Weng T, Shi N, Qi W, Guo Y, Chen T, Chen L, Xu D. The binding mechanism of NHWD-870 to bromodomain-containing protein 4 based on molecular dynamics simulations and free energy calculation Phys Chem Chem Phys. 2022 Feb 23;24(8):5125-5137._x000D_ 6: Hsu PL, Chien CW, Tang YA, Lin BW, Lin SC, Lin YS, Chen SY, Sun HS, Tsai SJ. Targeting BRD3 eradicates nuclear TYRO3-induced colorectal cancer metastasis Sci Adv. 2023 Apr 14;9(15):eade3422._x000D_ 7: Guo J, Zheng Q, Peng Y. BET proteins: Biological functions and therapeutic interventions Pharmacol Ther. 2023 Mar;243:108354._x000D_ 8: Rubio Gonzalez B, Ortiz MV, Ross DS, Busam KJ. Skin adnexal carcinoma with BRD3-NUTM2B fusion J Cutan Pathol. 2021 Dec;48(12):1508-1513._x000D_ 9: Seifritz T, Brunner M, Camarillo Retamosa E, Maciukiewicz M, KroÅ¡el M, Moser L, Züllig T, TomÅ¡ič M, Distler O, Ospelt C, Klein K. BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts Biomedicines. 2023 Nov 30;11(12):3188._x000D_ 10: Zhang X, Meng W, Liu D, Pan D, Yang Y, Chen Z, Ma X, Yin W, Niu M, Dong N, Liu J, Shen W, Liu Y, Lu Z, Chu C, Qian Q, Zhao M, Tong H. Enhancing rice panicle branching and grain yield through tissue-specific brassinosteroid inhibition Science. 2024 Mar 8;383(6687):eadk8838. _x000D_ _x000D_ Products Related to BRD3 (BD1+BD2), GST-tag Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2019122 (50 μg)_x000D_ BRD3 (BD1+BD2) is a recombinant protein that includes bromodomain-containing protein 3 (BRD3) with two bromodomains (BD1 and BD2) fused to a GST tag. It plays a role in gene expression regulation and is useful in molecular biology for studying BRD3 functions and interactions. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3