BRDT (BD2) GST-tag Recombinant

• Description:

  BRDT (BD2) GST-tag Recombinant_x000D_ Catalog number: B2019055_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 μg_x000D_ Molecular Weight or Concentration: 41.7 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: Bromodomain testis-specific protein, BRDT, BRD6, CT9_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Faivre EJ, McDaniel KF, Albert DH, Mantena SR, Plotnik JP, Wilcox D, Zhang L, Bui MH, Sheppard GS, Wang L, Sehgal V, Lin X, Huang X, Lu X, Uziel T, Hessler P, Lam LT, Bellin RJ, Mehta G, Fidanze S, Pratt JK, Liu D, Hasvold LA, Sun C, Panchal SC, Nicolette JJ, Fossey SL, Park CH, Longenecker K, Bigelow L, Torrent M, Rosenberg SH, Kati WM, Shen Y. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer Nature. 2020 Feb;578(7794):306-310._x000D_ 2: Jiang J, Sigua LH, Chan A, Kalra P, Pomerantz WCK, Schönbrunn E, Qi J, Georg GI. Dihydropyridine Lactam Analogs Targeting BET Bromodomains ChemMedChem. 2022 Jan 5;17(1):e202100407._x000D_ 3: Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM. Discovery and characterization of bromodomain 2-specific inhibitors of BRDT Proc Natl Acad Sci U S A. 2021 Mar 2;118(9):e2021102118._x000D_ 4: Modukuri RK, Yu Z, Tan Z, Ta HM, Ucisik MN, Jin Z, Anglin JL, Sharma KL, Nyshadham P, Li F, Riehle K, Faver JC, Duong K, Nagarajan S, Simmons N, Palmer SS, Teng M, Young DW, Yi JS, Kim C, Matzuk MM. Discovery of potent BET bromodomain 1 stereoselective inhibitors using DNA-encoded chemical library selections Proc Natl Acad Sci U S A. 2022 May 31;119(22):e2122506119._x000D_ 5: Miller TC, Simon B, Rybin V, Grötsch H, Curtet S, Khochbin S, Carlomagno T, Müller CW. A bromodomain-DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT Nat Commun. 2016 Dec 19;7:13855._x000D_ 6: Sheppard GS, Wang L, Fidanze SD, Hasvold LA, Liu D, Pratt JK, Park CH, Longenecker K, Qiu W, Torrent M, Kovar PJ, Bui M, Faivre E, Huang X, Lin X, Wilcox D, Zhang L, Shen Y, Albert DH, Magoc TJ, Rajaraman G, Kati WM, McDaniel KF. Discovery of N-Ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET Bromodomain Inhibitor with Selectivity for the Second Bromodomain J Med Chem. 2020 May 28;63(10):5585-5623._x000D_ 7: Wang Q, Li Y, Xu J, Wang Y, Leung EL, Liu L, Yao X. Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations Sci Rep. 2017 Aug 18;7(1):8857._x000D_ 8: Bharatham N, Slavish PJ, Shadrick WR, Young BM, Shelat AA. The role of ZA channel water-mediated interactions in the design of bromodomain-selective BET inhibitors J Mol Graph Model. 2018 May;81:197-210._x000D_ 9: Wahi A, Manchanda N, Jain P, Jadhav HR. Targeting the epigenetic reader "BET" as a therapeutic strategy for cancer Bioorg Chem. 2023 Nov;140:106833._x000D_ 10: Shi M, He J, Weng T, Shi N, Qi W, Guo Y, Chen T, Chen L, Xu D. The binding mechanism of NHWD-870 to bromodomain-containing protein 4 based on molecular dynamics simulations and free energy calculation Phys Chem Chem Phys. 2022 Feb 23;24(8):5125-5137. _x000D_ _x000D_ Products Related to BRDT (BD2) GST-tag Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2019055 (50 μg)_x000D_ BRDT (BD2) is a protein from the BRDT family, known for its role in male fertility. The BD2 contains a bromodomain that binds to acetylated lysine residues, influencing gene expression. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3