BRD4 (BD1), His-tag Recombinant

• Description:

  BRD4 (BD1), His-tag Recombinant_x000D_ Catalog number: B2019129_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 μg_x000D_ Molecular Weight or Concentration: 15.5 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: Bromodomain containing 4, BRD4, HUNK1, MCAP, BRD-4_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Gilan O, Rioja I, Knezevic K, Bell MJ, Yeung MM, Harker NR, Lam EYN, Chung CW, Bamborough P, Petretich M, Urh M, Atkinson SJ, Bassil AK, Roberts EJ, Vassiliadis D, Burr ML, Preston AGS, Wellaway C, Werner T, Gray JR, Michon AM, Gobbetti T, Kumar V, Soden PE, Haynes A, Vappiani J, Tough DF, Taylor S, Dawson SJ, Bantscheff M, Lindon M, Drewes G, Demont EH, Daniels DL, Grandi P, Prinjha RK, Dawson MA. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation Science. 2020 Apr 24;368(6489):387-394._x000D_ 2: Qian H, Zhu M, Tan X, Zhang Y, Liu X, Yang L. Super-enhancers and the super-enhancer reader BRD4: tumorigenic factors and therapeutic targets Cell Death Discov. 2023 Dec 22;9(1):470._x000D_ 3: Ma J, Chen H, Yang J, Yu Z, Huang P, Yang H, Zheng B, Liu R, Li Q, Hu G, Chen Z. Binding pocket-based design, synthesis and biological evaluation of novel selective BRD4-BD1 inhibitors Bioorg Med Chem. 2019 May 1;27(9):1871-1881._x000D_ 4: Mason JW, Chow YT, Hudson L, Tutter A, Michaud G, Westphal MV, Shu W, Ma X, Tan ZY, Coley CW, Clemons PA, Bonazzi S, Berst F, Briner K, Liu S, Zécri FJ, Schreiber SL. DNA-encoded library-enabled discovery of proximity-inducing small molecules Nat Chem Biol. 2024 Feb;20(2):170-179._x000D_ 5: Ding D, Zheng R, Tian Y, Jimenez R, Hou X, Weroha SJ, Wang L, Shi L, Huang H. Retinoblastoma protein as an intrinsic BRD4 inhibitor modulates small molecule BET inhibitor sensitivity in cancer Nat Commun. 2022 Oct 23;13(1):6311._x000D_ 6: Ibrahim MAA, Abdelhamid MMH, Abdeljawaad KAA, Abdelrahman AHM, Mekhemer GAH, Sidhom PA, Sayed SRM, Paré PW, Hegazy MF, Shoeib T. Pyronaridine as a Bromodomain-Containing Protein 4-N-Terminal Bromodomain (BRD4-BD1) Inhibitor: In Silico Database Mining, Molecular Docking, and Molecular Dynamics Simulation Molecules. 2023 Jul 28;28(15):5713._x000D_ 7: Liu Z, Li Y, Chen H, Lai HT, Wang P, Wu SY, Wold EA, Leonard PG, Joseph S, Hu H, Chiang CM, Brasier AR, Tian B, Zhou J. Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site J Med Chem. 2022 Feb 10;65(3):2388-2408._x000D_ 8: Qiao XP, Wang XT, Wang S, Mu HX, Wang QS, Chen SW. Discovery of indole-2-one derivatives as BRD4 (BD1) selective inhibitors Bioorg Med Chem. 2024 May 15;106:117752._x000D_ 9: Gupta A, Purohit R. Identification of potent BRD4-BD1 inhibitors using classical and steered molecular dynamics based free energy analysis J Cell Biochem. 2024 Mar;125(3):e30532._x000D_ 10: Divakaran A, Scholtz CR, Zahid H, Lin W, Griffith EC, Lee RE, Chen T, Harki DA, Pomerantz WCK. Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader ACS Med Chem Lett. 2022 Sep 29;13(10):1621-1627. _x000D_ _x000D_ Products Related to BRD4 (BD1), His-tag Recombinant can be found at Proteins

• Short Description:

  Catalog Number: B2019129 (50 μg)_x000D_ BRD4 (BD1), His-tag Recombinant is a laboratory-produced version of the first bromodomain of the BRD4 protein. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3