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HIF-2α-IN-2

CAT: 0013-GTR19177253-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19177253-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HIF-2α-IN-2 is a potent and selective small molecule inhibitor of hypoxia-inducible factor 2α, demonstrating an IC50 of 16 nM. This compound is a valuable research tool for studying HIF-2α's role in oncology and renal physiology through both in vitro and in vivo experimental models.
CAS Number
1672666-82-8
Product Name Alternative
Inhibit, HIFProlylHydroxylase, HIFs, HIF-PH, HIF-2α, HIF2αIN2, HIF-2α-IN-2, HIF-2a-IN-2, HIF-2alpha-IN-2, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF 2α IN 2, HIF ProlylHydroxylase, HIF, Inhibitor, Hypoxia-inducible factors
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research
Purity
99.24% (May vary between batches)
Solubility
DMSO:100 mg/mL (273.71 mM) ;10% DMSO+90% Corn Oil:3.3 mg/mL (9.03 mM)
Smiles
CS (=O) (=O) c1ccc (Oc2cc (F) cc (c2) C#N) c2CC (F) C (O) c12
Molecular Formula
C17H13F2NO4S
Molecular Weight
365.35
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

HIF-2alpha-IN-2
CAS Number1672666-82-8
PubChem CID117947105
IUPAC Name3-fluoro-5-[(2-fluoro-1-hydroxy-7-methylsulfonyl-2,3-dihydro-1H-inden-4-yl)oxy]benzonitrile
Molecular FormulaC17H13F2NO4S
Molecular Weight365.4
XLogP2.1
Topological Polar Surface Area95.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity643
SMILES
CS(=O)(=O)C1=C2C(C(CC2=C(C=C1)OC3=CC(=CC(=C3)C#N)F)F)O
InChI
InChI=1S/C17H13F2NO4S/c1-25(22,23)15-3-2-14(12-7-13(19)17(21)16(12)15)24-11-5-9(8-20)4-10(18)6-11/h2-6,13,17,21H,7H2,1H3
InChIKey
GTHLUQQEKIJSME-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of HIF-2alpha-IN-2
CAS: 1672666-82-8
CID: 117947105
Formula: C17H13F2NO4S
MW: 365.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.4
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass365.05333539
Monoisotopic Mass365.05333539
Topological Polar Surface Area95.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity643
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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