Products for Research Use Only
RegisterLogin

HIF-2α-IN-16

CAT: 0013-GTR19233905-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19233905-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HIF-2α-IN-16 (48) is a potent small molecule inhibitor of hypoxia-inducible factor 2α, exhibiting an IC50 of 91 nM. This compound is a valuable research tool for studying HIF-2α's role in oncology and renal physiology, applicable in both cellular and animal models of related diseases.
CAS Number
3033981-97-1
Field of Research
Epigenetics & Chromatin, Metabolism Research
Smiles
C (=O) (N1[C@]2 ([C@H] (O) C (F) (F) C1) CCC (F) (F) C2) C=3N=C (C (F) F) C (F) =CC3
Molecular Formula
C15H13F7N2O2
Molecular Weight
386.26
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Hif-2|A-IN-16
CAS Number3033981-97-1
PubChem CID171714334
IUPAC Name[6-(difluoromethyl)-5-fluoro-2-pyridinyl]-[(4S,5R)-3,3,8,8-tetrafluoro-4-hydroxy-1-azaspiro[4.4]nonan-1-yl]methanone
Molecular FormulaC15H13F7N2O2
Molecular Weight386.26
XLogP2.6
Topological Polar Surface Area53.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count2
Heavy Atom Count26
Formal Charge0
Complexity576
SMILES
C1CC(C[C@@]12[C@@H](C(CN2C(=O)C3=NC(=C(C=C3)F)C(F)F)(F)F)O)(F)F
InChI
InChI=1S/C15H13F7N2O2/c16-7-1-2-8(23-9(7)10(17)18)11(25)24-6-15(21,22)12(26)13(24)3-4-14(19,20)5-13/h1-2,10,12,26H,3-6H2/t12-,13+/m0/s1
InChIKey
PZXWEWHWRIXHNA-QWHCGFSZSA-N
Chemical Structure
2D Structure
2D structure of Hif-2|A-IN-16
CAS: 3033981-97-1
CID: 171714334
Formula: C15H13F7N2O2
MW: 386.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.26
XLogP32.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count2
Exact Mass386.08652480
Monoisotopic Mass386.08652480
Topological Polar Surface Area53.4 Ų
Heavy Atom Count26
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19177253-01HIF-2α-IN-2
GTR19155964-01HIF-2α-IN-2
GTR19187186-01HIF-2α-IN-6
GTR19233912-01HIF-2α-IN-12
GTR19205649-01HIF-2α-IN-3
GTR19187204-01HIF-1α-IN-2
GTR19187085-01HIF-PHD-IN-2
GTR19234165-01HIF-2α-IN-13
GTR19234164-01HIF-2α-IN-14
GTR19234037-01HIF-2α-IN-10

Alternative Products

CatalogName
T88307-01HIF-2α-IN-16
PA1129-SHIF-2α
XRC66682-01HIF-2α-IN-2
TBI1508-5MGHIF-2a-I2, HIF-2 antagonist
M32959-01HIF-2α-IN-3
M28457-01HIF-2α-IN-4
BA7799-5HIF-1α-IN-2
HY-19949-01HIF-2α-IN-1
T88052-01HIF-2α-IN-13
T61458-01HIF-PHD-IN-2

Popular Products