HIF-1/2α-IN-2

CAT: 0931-T61102-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T61102-01Size:25 mg

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CAS Number

862974-22-9

Target

Others, HIF/HIF Prolyl-Hydroxylase

Related Pathways

Metabolism, Others, Chromatin/Epigenetic

Bioactivity

HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α that effectively reduces HIF-1/2α levels and elicits an iron starvation response by specifically targeting ISCA2, a key protein in Iron-Sulfur Cluster Assembly 2. [1]

Smiles

COC1=CC=CC2=C1N=C(NC1=NN=C(O1)C1=CC=C(F)C=C1)S2

Molecular Formula

C16H11FN4O2S

Molecular Weight

342.35

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Chemical Information

5-(4-fluorophenyl)-N-(4-methoxy-1,3-benzothiazol-2-yl)-1,3,4-oxadiazol-2-amine

CAS Number	862974-22-9
PubChem CID	7109931
IUPAC Name	5-(4-fluorophenyl)-N-(4-methoxy-1,3-benzothiazol-2-yl)-1,3,4-oxadiazol-2-amine
Molecular Formula	C16H11FN4O2S
Molecular Weight	342.3
XLogP	4.1
Topological Polar Surface Area	101
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Heavy Atom Count	24
Formal Charge	0
Complexity	427

SMILES

COC1=C2C(=CC=C1)SC(=N2)NC3=NN=C(O3)C4=CC=C(C=C4)F

InChI

InChI=1S/C16H11FN4O2S/c1-22-11-3-2-4-12-13(11)18-16(24-12)19-15-21-20-14(23-15)9-5-7-10(17)8-6-9/h2-8H,1H3,(H,18,19,21)

InChIKey

TUNSTYGNRZSNSX-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 862974-22-9

CID: 7109931

Formula: C16H11FN4O2S

MW: 342.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	342.3
XLogP3	4.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	4
Exact Mass	342.05867494
Monoisotopic Mass	342.05867494
Topological Polar Surface Area	101 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	427
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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T61349-01	HIF-1α-IN-2
T15482-01	HIF-2α-IN-1
T61442-01	HIF-1/2α-IN-1
T78123-01	HIF-1α-IN-2 hydrochloride
T11561-01	HIF-2α-IN-2
T67831-01	HIF-2α agonist 2
T88052-01	HIF-2α-IN-13
T61458-01	HIF-PHD-IN-2
T11562-01	HIF-2α-IN-3
T78937-01	HIF-2α-IN-9

Alternative Products

Catalog	Name
GTR19187461-01	HIF-1/2α-IN-2
BA7799-5	HIF-1α-IN-2
HY-19949-01	HIF-2α-IN-1
BUP21313-01	HIF-2Î±-IN-1
HY-151341	HIF-1/2α-IN-1
XRC66682-01	HIF-2α-IN-2
HY-115903A-01	HIF-1α-IN-2 (hydrochloride)
GTR19231214-01	HIF-1α-IN-2 hydrochloride
HY-124079	HIF-1/2α-IN-3
MBS5803812	HIF-1/2alpha-IN-2

HIF-1/2α-IN-2

Chemical Information

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