Products for Research Use Only
RegisterLogin

ARRY-382

CAT: 0013-GTR19172192-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19172192-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ARRY-382 is a potent and selective small molecule inhibitor targeting the CSF-1R kinase, demonstrating an IC50 of 9 nM. It is utilized in preclinical research to investigate tumor-associated macrophages and has been applied in studies exploring oncology and inflammatory disease models both in vitro and in vivo.
CAS Number
1313407-95-2
Product Name Alternative
ARRY 382, ARRY382, ARRY-382, CSF1R, CSF-1R
Field of Research
Signal Transduction
Purity
99.24% (May vary between batches)
Solubility
DMSO:5 mg/mL (8.85 mM)
Smiles
N (C (=O) C=1N2C (=NC1) C=C (OCCN3CCN (C) CC3) C=C2) C4=C5C (=NN (CC=6N=C (C) C=CC6) C5=CC=C4) C7CC7
Molecular Formula
C32H36N8O2
Molecular Weight
564.68
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Arry-382

cFMS Tyrosine Kinase Inhibitor ARRY-382 is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.

CAS Number1313407-95-2
PubChem CID67259771
IUPAC NameN-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-[2-(4-methylpiperazin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide
Molecular FormulaC32H36N8O2
Molecular Weight564.7
XLogP3.9
Topological Polar Surface Area92.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count42
Formal Charge0
Complexity913
SMILES
CC1=NC(=CC=C1)CN2C3=CC=CC(=C3C(=N2)C4CC4)NC(=O)C5=CN=C6N5C=CC(=C6)OCCN7CCN(CC7)C
InChI
InChI=1S/C32H36N8O2/c1-22-5-3-6-24(34-22)21-40-27-8-4-7-26(30(27)31(36-40)23-9-10-23)35-32(41)28-20-33-29-19-25(11-12-39(28)29)42-18-17-38-15-13-37(2)14-16-38/h3-8,11-12,19-20,23H,9-10,13-18,21H2,1-2H3,(H,35,41)
InChIKey
JUPOTOIJLKDAPF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Arry-382
CAS: 1313407-95-2
CID: 67259771
Formula: C32H36N8O2
MW: 564.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight564.7
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass564.29612242
Monoisotopic Mass564.29612242
Topological Polar Surface Area92.8 Ų
Heavy Atom Count42
Formal Charge0
Complexity913
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19208138-01ARRY-502
GTR19196002-01ARRY-403
GTR19273131-01ARRY-371797
GTR19164717-01ARRY-797
GTR19209386-01NA 382
GTR19230408-01CAF-382
GTR19201074-01NCS-382
GTR19235102-01UBX-382
GTR19164449-01ARRY 520 hydrochloride
GTR19276299-01CRBN ligand-382

Alternative Products

CatalogName
BUP02454-01ARRY-382
A1947-50MEK162 (ARRY-162, ARRY-438162)
MBS577491Binimetinib (MEK162, ARRY-162, ARRY-438162)
A8366-10ARRY-380
HY-124065ARRY-502
LRB40417-01ARRY-797
T30142-01ARRY-403
MBS132255-01Arry 520

Popular Products