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PHA-767491

CAT: 0013-GTR19172077-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19172077-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHA-767491 is a potent, ATP-competitive dual inhibitor of Cdc7 and CDK9 kinases, exhibiting IC50 values of 10 nM and 34 nM, respectively. It is widely used in biochemical and cellular research to investigate DNA replication stress, transcription, and oncology-related pathways in both in vitro and in vivo models.
CAS Number
845714-00-3
Product Name Alternative
Cyclin dependent kinase, CAY10572, CAY-10572, CAY 10572, Cdc7, CDK1, CDK, CDK2, CDK9, inhibit, GSK3, GSK-3β, Inhibitor, PHA767491, PHA-767491, PHA 767491
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.42% (May vary between batches)
Solubility
DMSO:40 mg/mL (187.58 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
O=C1C=2C=C (NC2CCN1) C=3C=CN=CC3
Molecular Formula
C12H11N3O
Molecular Weight
213.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pha-767491

2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one is a pyrrolopyridine.

CAS Number845714-00-3
PubChem CID11715767
IUPAC Name2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
Molecular FormulaC12H11N3O
Molecular Weight213.23
XLogP0.6
Topological Polar Surface Area57.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count16
Formal Charge0
Complexity275
SMILES
C1CNC(=O)C2=C1NC(=C2)C3=CC=NC=C3
InChI
InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16)
InChIKey
DKXHSOUZPMHNIZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pha-767491
CAS: 845714-00-3
CID: 11715767
Formula: C12H11N3O
MW: 213.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight213.23
XLogP30.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass213.090211983
Monoisotopic Mass213.090211983
Topological Polar Surface Area57.8 Ų
Heavy Atom Count16
Formal Charge0
Complexity275
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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M19170-01PHA-767491
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