PHA-665752

CAT: 0013-GTR19171717-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19171717-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PHA-665752 is a potent and selective ATP-competitive inhibitor of the c-Met receptor tyrosine kinase, exhibiting an IC50 of 9 nM. It demonstrates over 50-fold selectivity against other kinases. This compound is a valuable research tool for studying c-Met signaling in cancer models, both in cellular assays and in vivo studies.

CAS Number

477575-56-7

Product Name Alternative

Flk1, FGFR1, HGFR, Inhibitor, inhibit, cMet, c-Met, cMet/HGFR, c-Met/HGFR, c-Abl, BcrAbl, Autophagy, Apoptosis, PHA 665752, PHA665752, PHA-665752, RON

Field of Research

Cardiovascular Research, Cell Biology, Metabolism Research, Signal Transduction

Purity

97.01% (May vary between batches)

Solubility

DMSO:50 mg/mL (77.93 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.12 mM)

Smiles

C (=C\1/C=2C (NC1=O) =CC=C (S (CC3=C (Cl) C=CC=C3Cl) (=O) =O) C2) \C4=C (C) C (C (=O) N5[C@@H] (CN6CCCC6) CCC5) =C (C) N4

Molecular Formula

C32H34Cl2N4O4S

Molecular Weight

641.61

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

(3Z)-5-(((2,6-Dichlorophenyl)methyl)sulfonyl)-3-((3,5-dimethyl-4-(((2R)-2-(1-pyrrolidinylmethyl)-1-pyrrolidinyl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one

PHA-665752 is a member of the class of indolones that is 1,3-dihydro-2H-indol-2-one which is substituted by a (2,6-dichlorobenzyl)sulfonyl group at position 5 and by a (1H-pyrrol-2-yl)methylidene group at position 2, the pyrrole ring of which is substituted by methyl groups at positions 3 and 5, and by a [2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl group at position 4 (the Z,R isomer). It has a role as an antineoplastic agent and a c-Met tyrosine kinase inhibitor. It is a secondary carboxamide, a tertiary carboxamide, a dichlorobenzene, a member of indolones, a sulfone, a N-acylpyrrolidine, a pyrrolecarboxamide and an enamide.

CAS Number	477575-56-7
PubChem CID	10461815
IUPAC Name	(3Z)-5-[(2,6-dichlorophenyl)methylsulfonyl]-3-[[3,5-dimethyl-4-[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidine-1-carbonyl]-1H-pyrrol-2-yl]methylidene]-1H-indol-2-one
Molecular Formula	C32H34Cl2N4O4S
Molecular Weight	641.6
XLogP	5
Topological Polar Surface Area	111
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Heavy Atom Count	43
Formal Charge	0
Complexity	1180

SMILES

CC1=C(NC(=C1C(=O)N2CCC[C@@H]2CN3CCCC3)C)/C=C\4/C5=C(C=CC(=C5)S(=O)(=O)CC6=C(C=CC=C6Cl)Cl)NC4=O

InChI

InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1

InChIKey

OYONTEXKYJZFHA-SSHUPFPWSA-N

Chemical Structure

2D Structure

CAS: 477575-56-7

CID: 10461815

Formula: C32H34Cl2N4O4S

MW: 641.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	641.6
XLogP3	5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	640.1677821
Monoisotopic Mass	640.1677821
Topological Polar Surface Area	111 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	1180
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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A2307-5.1	PHA-665752
abx076781-01	PHA 665752

PHA-665752

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